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Article

Polymorphisms in the protein C gene as risk factor for venous thrombosis.

Thrombosis and haemostasis - 1 Jan 2009

Pomp Elisabeth R, Doggen Carine J M, Vos Hans L, Reitsma Pieter H, Rosendaal Frits R

Abstract excerpt

Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphisms with factor V Leiden and oral contraceptive use was investigated. Previous studies on these...

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PMID: 19132190

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