Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population.

PloS one - 1 Jan 2012

Tang Liang, Guo Tao, Yang Rui, Mei Heng, Wang Huafang, Lu Xuan, Yu Jianming, Wang Qingyun, Hu Yu

Abstract excerpt

BACKGROUND: Protein C (PC) is one of the most important physiological inhibitors of coagulation proteases. Hereditary PC deficiency causes a predisposition to venous thrombosis (VT). The genetic characteristics of PC deficiency in the Chinese population remain unknown. METHODS: Thirty-four unrelated probands diagnosed with hereditary PC deficiency were investigated. PC activity and antigen levels were measured....

Read the complete abstract on PubMed

Topics

Adolescent
Adult
Aged
Amino Acid Sequence
Asian People
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Mutational Analysis

Humans

Middle Aged

Models, Molecular

Molecular Sequence Data

Mutation

Mutation, Missense

Pedigree

Protein C

Protein C Deficiency

Sequence Alignment

Venous Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22545135
DOI: 10.1371/journal.pone.0035773
PMCID: PMC3335791

Genes

PROC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population.PMID 22545135Read ↗

PROC c.574_576del polymorphism: a common genetic risk factor for venous thrombosis in the Chinese population.Semantic proximity Read ↗

Familial thrombotic risk based on the genetic background of Protein C Deficiency in a Portuguese Study.Semantic proximity Read ↗

Analysis of Four Hereditary Protein C Deficiencies Associated with Vascular ThromboembolismSemantic proximity Read ↗

Analysis of four hereditary protein C deficiencies associated with vascular thromboembolism.Semantic proximity Read ↗

Clinical and genetic features of protein C deficiency in 23 unrelated Chinese patients.Semantic proximity Read ↗

Molecular and clinical characterization of two independent Chinese families with protein C deficiencySemantic proximity Read ↗

Compound heterozygous protein C deficiency with pulmonary embolism caused by a novel PROC gene mutation: Case report and literature review.Semantic proximity Read ↗

Anticoagulant protein C p.Lys193del mutation and promoter region polymorphisms :common genetic risk factors of deep venous thrombosis in Chinese populationSemantic proximity Read ↗

[Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families].Semantic proximity Read ↗

Genetic variations and their influence on risk and treatment of venous thrombosis.Semantic proximity Read ↗

A comprehensive study of antithrombin deficiency in a large cohort of Chinese thrombophilia pedigrees: uncovering 4 SERPINC1 pathogenic variants merely impaired progressive activities.Semantic proximity Read ↗

Common genetic risk factors for venous thrombosis in the Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.