Article
Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus.
Journal of virology - 1 Apr 1992
Bergeron L, Sullivan N, Sodroski J
Abstract excerpt
The entry of human immunodeficiency virus type 1 (HIV-1) into target cells involves binding to the viral receptor (CD4) and membrane fusion events, the latter influenced by target cell factors other than CD4. The third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein and the amino terminus of the HIV-1 gp41 transmembrane envelope glycoprotein have been shown to be important for the membrane...
Topics
- Amino Acid Sequence
- CD4 Antigens
- Cell Line
- Genetic Complementation Test
- Giant Cells
- Glycosylation
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Membrane Fusion