Article
An inducible, nondegradative phytoalexin resistance mechanism in Dictyostelium discoideum is suppressed by mutations that alter membrane sterol composition.
Applied and environmental microbiology - 1 Jun 1992
Kasbekar D P, Papavinasasundaram K G
Abstract excerpt
Pretreatment of Dictyostelium discoideum amoebae with a sublethal concentration of the pea phytoalexin pisatin was shown to induce nondegradative resistance to subsequent challenges with inhibitory concentrations. An alteration of membrane sterol composition either with the azasterol A25822B or by mutations in nysC that confer resistance to the polyene antibiotic nystatin suppressed the induction of pisatin...
Topics
- Animals
- Benzopyrans
- Cholestadienols
- Dictyostelium
- Drug Resistance
- Membrane Lipids
- Models, Biological
- Mutation
- Nystatin
- Plant Extracts
- Pterocarpans