Article
Application of a polymorphic Y microsatellite to the detection of post bone marrow transplantation chimaerism.
British journal of haematology - 1 Mar 1995
Lo Y M, Noakes L, Roux E, Jeannet M, Chapuis B, Fleming K A, Wainscoat J S
Abstract excerpt
A highly sensitive Y-microsatellite amplification system was developed for the detection of post bone marrow transplantation (BMT) chimaerism. The system is able to detect the DNA equivalent of a single male cell in a background of 10(5) female cells. For clinical applications it has the distinct...
Topics
- Alleles
- Base Sequence
- Bone Marrow Transplantation
- DNA, Satellite
- Female
- Humans
- Leukemia
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sensitivity and Specificity
- Transplantation Chimera
- Y Chromosome