Article
bcl-2 expression in myelodysplastic syndromes and its correlation with hematological features, p53 mutations and prognosis.
Leukemia - 1 Apr 1995
Lepelley P, Soenen V, Preudhomme C, Merlat A, Cosson A, Fenaux P
Abstract excerpt
We looked for bcl-2 protein expression by immunocytochemistry on bone marrow slides from 51 cases of myelodysplastic syndrome (MDS), of whom 25 received some form of chemotherapy. Forty-six of them had at least 20% bcl-2 positive blasts and the median percentage of positive blasts was 80%, whereas myeloid cells beyond blasts were always negative. No correlation was found between bcl-2 expression and the FAB type...
Topics
- Gene Expression
- Genes, p53
- Humans
- Mutation
- Myelodysplastic Syndromes
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- RNA, Messenger