[The reversing effect of 4-hydroxycarbophenyl retiamide (R II) on the malignant phenotype of mouse forestomach carcinoma (MFC) cell line and the mechanism of its action].

Abstract excerpt

4-hydroxycarbophenyl retiamide (R II) is a new synthetic analogue of retinol, but with lower toxicity than retinoic acid. We studied its induction effects and its effects on some malignant phenotypes of the MFC cell line. The mechanism of these effects was also explored. MFC cells were grown in complete RPMI 1640 medium supplemented with 10(-5) mol/L R II for five passages. By then the cell growth rate slowed...

Topics

• Animals
• Antineoplastic Agents
• Cell Transformation, Neoplastic
• Gene Expression Regulation, Neoplastic
• Genes, fos
• Genes, myc
• Mice
• Mice, Inbred Strains
• Phenotype
• RNA, Messenger