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Article

Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype.

Arthritis and rheumatism - 1 Apr 1995

Venn G, Billingham M E, Hardingham T E

Abstract excerpt

OBJECTIVE: To determine whether chondrocytes in early experimental osteoarthritic (OA) cartilage continue to show increased synthesis and turnover of proteoglycans (PGs) during explant culture. A comparison was also made between the responsiveness of experimental OA and control cartilage to interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) after 1 day and 3 days in culture. METHODS: OA...

Topics

Aggrecans
Animals
Biglycan
Cartilage, Articular
Culture Techniques
Decorin
Dogs
Extracellular Matrix Proteins
Female
Lectins, C-Type
Osteoarthritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proteoglycans

Reference Values

Time Factors

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 7718006
DOI: 10.1002/art.1780380410

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7718006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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