Cloning of a human cDNA for protoporphyrinogen oxidase by complementation in vivo of a hemG mutant of Escherichia coli.

doi:10.1074/jbc.270.14.8076

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Article

Cloning of a human cDNA for protoporphyrinogen oxidase by complementation in vivo of a hemG mutant of Escherichia coli.

The Journal of biological chemistry - 7 Apr 1995

Nishimura K, Taketani S, Inokuchi H

Abstract excerpt

Protoporphyrinogen oxidase (PPO; EC 1.3.3.4) is the enzyme that catalyzes in the penultimate step in the heme biosynthetic pathway. Hemes are essential components of redox enzymes, such as cytochromes. Thus, a hemG mutant strain of Escherichia coli deficient in PPO is defective in aerobic respira...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cloning, Molecular
DNA, Complementary
Escherichia coli
Escherichia coli Proteins
Flavoproteins
Genetic Complementation Test
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondria, Liver

Mitochondrial Proteins

Molecular Sequence Data

Mutation

Oxidoreductases

Oxidoreductases Acting on CH-CH Group Donors

Source

Open in PubMed

Identifiers

PMID: 7713909
DOI: 10.1074/jbc.270.14.8076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7713909-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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