Mutation in dipZ leads to reduced production of active human placental alkaline phosphatase in Escherichia coli.

doi:10.1016/0378-1097(94)90251-8

Back to search

Article

Mutation in dipZ leads to reduced production of active human placental alkaline phosphatase in Escherichia coli.

FEMS microbiology letters - 1 Dec 1994

Beck R, Crooke H, Jarsch M, Cole J, Burtscher H

Abstract excerpt

We have tested the expression of alkaline phosphatases in a mutant strain of Escherichia coli deficient in dipZ, a gene coding for a protein involved in cytochrome c biogenesis, and the isogenic wild-type strain. The yield of soluble and active human placental alkaline phosphatase was significant...

Topics

Alkaline Phosphatase
Escherichia coli
Female
Humans
Mutation
Oxidoreductases
Placenta
Plasmids
Pregnancy
Recombinant Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.