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Regulation of Telomere Homeostasis during Epstein-Barr virus Infection and Immortalization

9 Aug 2017

Abstract excerpt

The acquisition of unlimited proliferative potential is dependent on the activation of mechanisms for telomere maintenance, which counteracts telomere shortening and the consequent triggering of the DNA damage response, cell cycle arrest, and apoptosis. The capacity of Epstein Barr virus (EBV) to infect B-lymphocytes in vitro and transform the infected cells into autonomously proliferating immortal cell lines...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 28792435
DOI: 10.3390/v9080217

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