Article
Identification of drug-related genotypic changes in HIV-1 from serum using the selective polymerase chain reaction.
Antiviral research - 1 Dec 1994
Anderson B D, Shirasaka T, Kojima E, Yarchoan R, Mitsuya H
Abstract excerpt
We attempted to detect drug-related HIV-1 pol gene mutations by selective polymerase chain reaction (PCR) using both proviral DNA and viral RNA isolated from patients (pts) with AIDS or ARC receiving antiretroviral therapy. Peripheral blood mononuclear cell (PBM)-associated proviral DNA and serum...
Topics
- Antiviral Agents
- Base Sequence
- DNA Primers
- DNA, Viral
- Didanosine
- Efficiency
- Evaluation Studies as Topic
- Genes, pol
- Genotype
- HIV Infections
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Proviruses
- RNA, Viral