[Expression of p53 in the skin in systemic sclerosis. Immunohistochemical study of 8 cases].

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Article

[Expression of p53 in the skin in systemic sclerosis. Immunohistochemical study of 8 cases].

Pathologica - 1 Aug 1994

Pignone A, Calzolari A, Cerinic M M, Scaletti C, Messerini L, Lombardi A, Generini S, Giannelli E, Carossino A, Baroni G

Abstract excerpt

P53 gene belongs to the family of "Tumor suppressor gene". It encodes a nuclear phosphoprotein involved in cell proliferation control; mutations of p53 gene are the most common genetic alterations found in human tumors. These mutations may cause the production of an altered protein that usually l...

Topics

Adult
Antibodies, Monoclonal
Biopsy
Epidermis
Female
Gene Expression
Humans
Immunoenzyme Techniques
Keratinocytes
Middle Aged
Mutation
Paraffin Embedding
Scleroderma, Systemic
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7708439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7708439-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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