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Article

Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.

Journal of virology - 1 May 1995

Wattel E, Vartanian J P, Pannetier C, Wain-Hobson S

Abstract excerpt

Human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-associated myelopathy. Both diseases are usually preceded by a long clinically asymptomatic period. PCR amplification of the HTLV-I proviral integration sites shows that clonal expansion of HTLV-I-bearing T cells, rather than being an occasional phenomenon in nonmalignant disease, is...

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Identifiers

PMID: 7707509
DOI: 10.1128/JVI.69.5.2863-2868.1995
PMCID: PMC188982

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