Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.

Abstract excerpt

Human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-associated myelopathy. Both diseases are usually preceded by a long clinically asymptomatic period. PCR amplification of the HTLV-I proviral integration sites shows that clonal expansion of HTLV-I-bearing T cells, rather than being an occasional phenomenon in nonmalignant disease, is...

Topics

• Adult
• Base Sequence
• Carrier State
• Cloning, Molecular
• DNA Primers
• DNA, Viral
• Female
• Genetic Variation
• HTLV-I Infections
• Human T-lymphotropic virus 1
• Humans