Article
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
The Journal of clinical investigation - 1 Apr 1995
Turki J, Pak J, Green S A, Martin R J, Liggett S B
Abstract excerpt
Nocturnal asthma represents a unique subset of patients with asthma who experience worsening symptoms and airflow obstruction at night. The basis for this phenotype of asthma is not known, but beta 2-adrenergic receptors (beta 2AR) are known to downregulate overnight in nocturnal asthmatics but n...
Topics
- Alleles
- Asthma
- Base Sequence
- Cohort Studies
- Female
- Forced Expiratory Volume
- Genotype
- Glycine
- Heterozygote
- Homozygote
- Humans
- Male
- Molecular Sequence Data
- Peak Expiratory Flow Rate
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Adrenergic, beta-2