Article
Association of beta2-adrenoreceptor polymorphisms with nocturnal cough among atopic subjects but not with atopy and nonspecific bronchial hyperresponsiveness.
The Journal of allergy and clinical immunology - 1 Apr 2002
Kim Sang-Hoon, Oh Sun-Young, Oh Heung-Bum, Kim Yoon-Keun, Cho Sang-Heon, Kim You-Young, Min Kyung-Up
Abstract excerpt
BACKGROUND: The reports from in vitro studies that beta(2)-adre-nergic receptor (B2AR) polymorphisms are associated with agonist-promoted downregulation have evoked considerable research interest for the roles of these polymorphisms to the pathogenesis of asthma. OBJECTIVE: We sought to evaluate the association between asthma phenotypes and B2AR polymorphisms at 2 sites (Arg16 --> Gly16 and Gln27 --> Glu27) in...
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