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Article

The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours.

Clinical endocrinology - 1 Feb 1995

Greenman Y, Prager D, Melmed S

Abstract excerpt

BACKGROUND AND OBJECTIVE: Clinical acromegaly is characterized by dysregulation of somatotroph GH secretion in the presence of high circulating serum IGF-I levels. Physiologically, IGF-I exerts a negative feedback on GH secretion at both the hypothalamic and the pituitary levels. We have previous...

Topics

Base Sequence
DNA, Neoplasm
Exons
Growth Hormone
Humans
Molecular Sequence Data
Mutation
Pituitary Neoplasms
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Receptor, IGF Type 1
Sequence Analysis, DNA

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Identifiers

PMID: 7704960
DOI: 10.1111/j.1365-2265.1995.tb01858.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7704960-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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