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Article

The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours.

Clinical endocrinology - 1 Feb 1995

Greenman Y, Prager D, Melmed S

Abstract excerpt

BACKGROUND AND OBJECTIVE: Clinical acromegaly is characterized by dysregulation of somatotroph GH secretion in the presence of high circulating serum IGF-I levels. Physiologically, IGF-I exerts a negative feedback on GH secretion at both the hypothalamic and the pituitary levels. We have previously shown that the 943 and 950 tyrosine residues in the IGF-I receptor beta-subunit are required for ligand signalling...

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Identifiers

PMID: 7704960
DOI: 10.1111/j.1365-2265.1995.tb01858.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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