Article
Apo E genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease.
Molecular and cellular probes - 1 Dec 1994
Rubinsztein D C, Hanlon C S, Irving R M, Goodburn S, Evans D G, Kellar-Wood H, Xuereb J H, Bandmann O, Harding A E
Abstract excerpt
Apolipoprotein E (apo E) exists in three allelic, functionally distinct isoforms (apo E2, E3 and E4). Recent work has suggested that apo-E-dependent uptake of lipoproteins may play important roles in the development and maintenance of the nervous system and in the responses to both peripheral and central nervous system injury. If apo-E-mediated transport of lipids were a rate-limiting step in these processes, one...
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