Article
A hammerhead ribozyme inhibits ADE1 gene expression in yeast.
Gene - 21 Mar 1995
Ferbeyre G, Bratty J, Chen H, Cedergren R
Abstract excerpt
To study factors that affect in vivo ribozyme (Rz) activity, a model system has been devised in Saccharomyces cerevisiae based on the inhibition of ADE1 gene expression. This gene was chosen because Rz action can be evaluated visually by the Red phenotype produced when the activity of the gene product is inhibited. Different plasmid constructs allowed the expression of the Rz either in cis or in trans with...
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