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Article

Translational suppression by hammerhead ribozymes and inactive variants in S. cerevisiae.

Biomolecular engineering - 1 Jun 2000

Yim S H, Park I, Ahn J K, Kang C

Abstract excerpt

The activity of hammerhead ribozymes in S. cerevisiae was assessed using two ribozymes that were designed to intramolecularly attack the hepatitis B viral X mRNA. The ribozymes effectively suppressed the expression of the X-lacZ fusion gene, when they were inserted at the 5' end of the X mRNA. The ribozymes cleaved the target RNA efficiently at the targeted phosphodiester bond, but the inactive mutants carrying...

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Identifiers

PMID: 10894112
DOI: 10.1016/s1389-0344(99)00052-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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