Article
Intervention of geminiviral replication in yeast by ribozyme mediated downregulation of its Rep protein.
FEBS letters - 12 Jun 2007
Chilakamarthi Ushasri, Mukherjee Sunil K, Deb J K
Abstract excerpt
Geminiviruses pose serious threat to many economically important crops such as mungbean, tomato, cotton, etc. To devise a specific antiviral strategy at the viral DNA replication level, a hammerhead ribozyme was directed against the mRNA of the replication initiator protein (Rep). Rep is the most important viral protein for the DNA replication of the Mungbean yellow mosaic India virus (MYMIV), a member of the...
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