Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

doi:10.1002/j.1460-2075.1993.tb06106.x

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Article

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

The EMBO journal - 1 Nov 1993

Müller M, Laxton C, Briscoe J, Schindler C, Improta T, Darnell J E, Stark G R, Kerr I M

Abstract excerpt

Mutants in complementation group U3, completely defective in the response of all genes tested to interferons (IFNs) alpha and gamma, do not express the 91 and 84 kDa polypeptide components of interferon-stimulated gene factor 3 (ISGF3), a transcription factor known to play a primary role in the IFN-alpha response pathway. The 91 and 84 kDa polypeptides are products of a single gene. They result from differential...

Topics

Base Sequence
Cell Line
DNA-Binding Proteins
Fibroblasts
Genetic Complementation Test
Humans
Interferon-Stimulated Gene Factor 3
Interferon-Stimulated Gene Factor 3, gamma Subunit
Interferon-alpha
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferons

Molecular Sequence Data

Mutation

Protein Conformation

RNA, Messenger

Signal Transduction

Transcription Factors

Transcription, Genetic

Source

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Identifiers

PMID: 7693454
DOI: 10.1002/j.1460-2075.1993.tb06106.x
PMCID: PMC413716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7693454-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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