Article
Molecular mechanisms and implications for infection of lipopolysaccharide variation in Neisseria.
Molecular microbiology - 1 Jun 1995
van Putten J P, Robertson B D
Abstract excerpt
The lipopolysaccharides of the pathogenic Neisseria species are subject to structural variation owing to a combination of intrinsic changes in lipopolysaccharide (LPS) biosynthesis and external modification of the LPS molecule with sialic acid. This variation appears to control bacterial behaviour by altering their ability to interact with human cells and to evade host immune defences. This interconversion of LPS...
Topics
- Carbohydrate Conformation
- Carbohydrate Sequence
- Genetic Variation
- Humans
- Lipopolysaccharides
- Molecular Sequence Data
- Mucous Membrane
- Neisseria
- Neisseriaceae Infections
- Oligosaccharides