Article
CD4-positive lymphoid cells rescue HIV-1 replication from abortively infected human primary endothelial cells.
Archives of virology - 1 Jan 1993
Scheglovitova O, Capobianchi M R, Antonelli G, Guanmu D, Dianzani F
Abstract excerpt
Human primary endothelial cell cultures, derived from umbilical vein (HUVEC), can be infected by different strains of HIV-1, but mature virus production remains undetectable both in supernatants and in cellular extracts. Yet viral DNA is transiently detectable during the first days of infection, but progressively declines during the subsequent days. This finding is characteristic of abortive infections....
Topics
- Antibodies, Monoclonal
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Culture Techniques
- Cytopathogenic Effect, Viral
- Endothelium, Vascular
- Galactosylceramides
- Genetic Variation
- HIV-1
- Humans