Article
Maternal HIV type 1 infection suppresses MMP-1 expression in endothelial cells of uninfected newborns: nonviral vertical transmission of HIV type 1-related effects.
AIDS research and human retroviruses - 1 Nov 2005
Jörg Anita, Grubert Thomas, Grimm Thomas, Guenzi Eric, Naschberger Elisabeth, Samson Elenore, Oostendorp Robert, Keller Ulrich, Stürzl Michael
Abstract excerpt
HIV-1 infection is associated with vascular alterations. This is accompanied by an increased risk of cardiovascular diseases and Kaposi's sarcoma, an endothelial cell-derived tumor. We investigated the impact of maternal HIV-1 infection on phenotype and gene expression of endothelial cells in newborns. For this reason endothelial precursor cells and differentiated endothelial cells were isolated from cord blood...
Topics
- Anti-HIV Agents
- Blotting, Western
- Cell Separation
- Cells, Cultured
- DNA
- DNA Methylation
- Endothelial Cells
- Epigenesis, Genetic
- Female
- Fetal Blood
- HIV Infections
- HIV-1
- Humans