Article
Altered DNA ligase I activity in Bloom's syndrome cells.
Nature - 1 Jan 2000
Chan J Y, Becker F F, German J, Ray J H
Abstract excerpt
Cells from patients with Bloom's syndrome, a rare disease associated with increased cancer frequency, exhibit cytological abnormalities. These include increased numbers of homologous chromatid interchange figures and sister-chromatid exchanges, together with abnormally slow replicon-fork progress...
Topics
- Bloom Syndrome
- Cell Line
- DNA Ligases
- DNA Replication
- DNA-Directed DNA Polymerase
- Humans
- Lymphocytes
- Mutation
- Polynucleotide Ligases