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Dengue-3 virus genomic differences that correlate with in vitro phenotype on a human cell line but not with disease severity.

Microbes and infection - 1 Jan 2007

Roche Claudine, Cassar Olivier, Laille Manola, Murgue Bernadette

Abstract excerpt

We compared the full genome sequence of nine clinical isolates of dengue virus obtained during an epidemic of dengue-3 in French Polynesia in 1989, from patients with various presentations of disease. The isolates, all belonging to Genotype I, had 25 amino acid substitutions. There was no association with disease severity. When cultured in the K562 human erythroleukemia cell line, the isolates induced a range of...

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PMID: 17196421
DOI: 10.1016/j.micinf.2006.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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