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Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase.

Nature genetics - 1 Aug 1995

Mune T, Rogerson F M, Nikkilä H, Agarwal A K, White P C

Abstract excerpt

The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of human hypertension thought to result from a deficiency of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). This enzyme normally converts cortisol to inactive cortisone and is postulated to thus confer specificity for aldosterone upon the mineralocorticoid receptor. We have analysed the gene encoding the kidney isozyme of 11 beta...

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PMID: 7670488
DOI: 10.1038/ng0895-394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase.PMID 7670488Read ↗

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11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess.Semantic proximity Read ↗

Human hypertension caused by mutations in the 11 beta-hydroxysteroid dehydrogenase gene: a molecular analysis of apparent mineralocorticoid excess.Semantic proximity Read ↗

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Apparent mineralocorticoid excess: comprehensive overview of molecular geneticsSemantic proximity Read ↗

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Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene.Semantic proximity Read ↗

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