Article
Single-headed myosin II acts as a dominant negative mutation in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995
Burns C G, Larochelle D A, Erickson H, Reedy M, De Lozanne A
Abstract excerpt
Conventional myosin II is an essential protein for cytokinesis, capping of cell surface receptors, and development of Dictyostelium cells. Myosin II also plays an important role in the polarization and movement of cells. All conventional myosins are double-headed molecules but the significance of this structure is not understood since single-headed myosin II can produce movement and force in vitro. We found that...
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