Article
Transferrin C2 and Alzheimer's disease: another piece of the puzzle found?
Medical hypotheses - 1 Apr 1995
Van Rensburg S J, Carstens M E, Potocnik F C, van der Spuy G, van der Walt B J, Taljaard J J
Abstract excerpt
A significant increase in the occurrence of the transferrin C2 genetic subtype has been found in patients with Alzheimer's disease. This variant has previously been linked to diseases thought to be associated with free radical damage. We hypothesize that Alzheimer's disease is caused by free radical damage to membranes of endocytic vesicles due to defective binding of iron and aluminium by Tf C2. The aluminium...
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