Article
Prenatal diagnosis of beta-thalassaemia and sickle cell anaemia in Turkey.
Prenatal diagnosis - 1 Mar 1996
Tüzmen S, Tadmouri G O, Ozer A, Baig S M, Ozçelik H, Başaran S, Başak A N
Abstract excerpt
This paper reports our experience of molecular analysis and diagnosis of beta-thalassaemia and sickle cell anaemia (HbS) in 70 prospective parents of Turkish descent and their fetuses. Molecular screening was carried out by allele-specific oligonucleotide (ASO) hybridization of amplified DNA to the 12 most common mutations in the Turkish population. By using this approach, we were able to define the mutation in...
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