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Article

Development of Antibiotic Resistance during Simulated Treatment of Pseudomonas aeruginosa in Chemostats.

PloS one - 1 Jan 2016

Feng Yanfang, Hodiamont Caspar J, van Hest Reinier M, Brul Stanley, Schultsz Constance, Ter Kuile Benno H

Abstract excerpt

During treatment of infections with antibiotics in critically ill patients in the intensive care resistance often develops. This study aims to establish whether under those conditions this resistance can develop de novo or that genetic exchange between bacteria is by necessity involved. Chemostat cultures of Pseudomonas aeruginosa were exposed to treatment regimes with ceftazidime and meropenem that simulated...

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Identifiers

PMID: 26872140
DOI: 10.1371/journal.pone.0149310
PMCID: PMC4752458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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