Article
Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q- syndrome: delineation of the critical region on 5q and identification of a 5q- breakpoint.
Genomics - 1 Feb 1994
Boultwood J, Fidler C, Lewis S, Kelly S, Sheridan H, Littlewood T J, Buckle V J, Wainscoat J S
Abstract excerpt
Molecular mapping techniques have defined the region of gene loss in two patients with the 5q- syndrome and uncharacteristically small 5q deletions (5q31-q33). The allelic loss of 10 genes localized to 5q23-qter (centromere-CSF2-EGR1-FGFA-GRL-ADRB2-CS F1R-SPARC-GLUH1-NKSF1-FLT4-telomere) was investigated in peripheral blood cell fractions. Gene dosage experiments demonstrated that CSF2, EGR1, NKSF1, and FLT4 were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.