Article
Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin.
The FEBS journal - 1 Jun 2008
Kukimoto Iwao, Mori Seiichiro, Sato Hidetaka, Takeuchi Takamasa, Kanda Tadahito
Abstract excerpt
Human papillomavirus type 16 (HPV16) DNA replication, which requires two viral proteins E1 and E2, occurs only in the differentiating epithelium. Besides the general factors necessary for cellular DNA synthesis, other unidentified cellular factors are assumed to be involved in the regulation of HPV DNA replication. In the present study, we found that the POU-domain transcription factor human Skn-1a, which induces...
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