The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli.

doi:10.1172/JCI118110

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Article

The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli.

The Journal of clinical investigation - 1 Aug 1995

Cross A, Asher L, Seguin M, Yuan L, Kelly N, Hammack C, Sadoff J, Gemski P

Abstract excerpt

Extraintestinally invasive Escherichia coli (EC) that possess both a complete LPS and K1 capsule evade both complement-mediated bacteriolysis and neutrophil-mediated killing. Since C3H/HeJ mice that are hyporesponsive to LPS were uniquely susceptible to lethal infection with EC of this phenotype, we speculated there was an LPS-initiated host defense mechanism against this pathogenic phenotype. The...

Topics

Animals
Antigens, Bacterial
Antigens, Surface
Bacteremia
Bacterial Capsules
Bacteriolysis
Cells, Cultured
Cytokines
Endotoxins
Escherichia coli
Escherichia coli Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Predisposition to Disease

Immunologic Factors

Interferon-gamma

Interleukin-1

Kupffer Cells

Lethal Dose 50

Source

Open in PubMed Open full text

Identifiers

PMID: 7635960
DOI: 10.1172/JCI118110
PMCID: PMC185248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7635960-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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