Article
Lack of association between the Tlr4 (Lpsd/Lpsd) genotype and increased susceptibility to Escherichia coli bladder infections in female C3H/HeJ mice.
mBio - 1 Jan 2011
Suhs Kaleigh A, Marthaler Brodie R, Welch Rodney A, Hopkins Walter J
Abstract excerpt
UNLABELLED: Toll-like receptor 4 is thought to have a primary role in host defense against Escherichia coli bladder colonization, based on mouse models of urinary tract infection using C3H/HeJ female mice. This strain carries a point mutation in the Tlr4 gene, which renders the mice unresponsive to lipopolysaccharide (LPS) and thus limits the bladder inflammatory response and infection resolution. The importance...
Topics
- Animals
- Crosses, Genetic
- Escherichia coli Infections
- Female
- Genetic Predisposition to Disease
- Genotype
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Toll-Like Receptor 4
- Urinary Bladder
- Urinary Tract Infections