Article
Lack of evidence for a role of HLA-DP in unexplained recurrent spontaneous abortion.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine - 1 Jan 1995
Sagot P, Bignon J, Cesbron A, Cheneau M L, Boog G, Muller J Y
Abstract excerpt
Using the "Polymerase Chain Reaction-Sequence Specific Oligoprobes" (PCR-SSOp) technique, we studied the HLA-DPB locus in both partners of 59 couples with a history of three spontaneous abortions, and of 38 control couples in order to determine the role of this centromeric region of the major histocompatibility complex (MHC) in the immune reaction needed for a favorable course of pregnancy. As no particular...
Topics
- Abortion, Habitual
- Case-Control Studies
- Chromosome Mapping
- DNA Probes, HLA
- Female
- Genes, MHC Class II
- HLA-DP Antigens
- Homozygote
- Humans
- Infertility
- Male