Article
The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
The EMBO journal - 3 Jul 1995
Rajendra S, Vandenberg R J, Pierce K D, Cunningham A M, French P W, Barry P H, Schofield P R
Abstract excerpt
A loop structure, formed by the putative disulfide bridging of Cys198 and Cys209, is a principal element of the ligand binding site in the glycine receptor (GlyR). Disruption of the loop's tertiary structure by Ser mutations of these Cys residues either prevented receptor assembly on the cell surface, or created receptors unable to be activated by agonists or to bind the competitive antagonist, strychnine....
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