Article
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
The Biochemical journal - 1 Jul 1995
Liang Y, Kesavan P, Wang L Q, Niswender K, Tanizawa Y, Permutt M A, Magnuson M A, Matschinsky F M
Abstract excerpt
Mutations in the human glucokinase (GK) gene are thought to cause maturity-onset diabetes of youth (MODY) by leading to the production of enzymes with reduced catalytic activities and increased glucose Km values. However, in some cases the diabetic phenotype is more severe than might be predicted from these apparent kinetic effects alone. To determine whether these mutations might also effect other...
Topics
- Adenosine Triphosphate
- Age of Onset
- Animals
- Base Sequence
- DNA Primers
- Diabetes Mellitus, Type 2
- Enzyme Stability
- Glucokinase
- Glutathione Transferase
- Hexokinase
- Humans