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Article

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.

The Biochemical journal - 1 Jul 1995

Liang Y, Kesavan P, Wang L Q, Niswender K, Tanizawa Y, Permutt M A, Magnuson M A, Matschinsky F M

Abstract excerpt

Mutations in the human glucokinase (GK) gene are thought to cause maturity-onset diabetes of youth (MODY) by leading to the production of enzymes with reduced catalytic activities and increased glucose Km values. However, in some cases the diabetic phenotype is more severe than might be predicted from these apparent kinetic effects alone. To determine whether these mutations might also effect other...

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Identifiers

PMID: 7619052
DOI: 10.1042/bj3090167
PMCID: PMC1135815

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.PMID 7619052Read ↗

Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.Semantic proximity Read ↗

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.Semantic proximity Read ↗

Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.Semantic proximity Read ↗

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.Semantic proximity Read ↗

Characterization of two MODY2 mutations with different susceptibility to activation.Semantic proximity Read ↗

A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.Semantic proximity Read ↗

Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.Semantic proximity Read ↗

Biochemical Basis of Glucokinase Activation and the Regulation by Glucokinase Regulatory Protein in Naturally Occurring MutationsSemantic proximity Read ↗

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.Semantic proximity Read ↗

Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.Semantic proximity Read ↗

Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.Semantic proximity Read ↗

Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).Semantic proximity Read ↗

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