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Article

A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.

FEBS letters - 1 Jun 2023

Aránguiz Oscar, Rivera Rodrigo, Durruty Pilar, Seelenfreund Daniela, Báez Mauricio

Abstract excerpt

Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK associated with maturity-onset diabetes of the young type 2 (MODY2) previously described reduce the functionality of the human pancreatic β-cell, leading to diabetic clinical phenotypes....

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Identifiers

PMID: 36520489
DOI: 10.1002/1873-3468.14561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.PMID 36520489Read ↗

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