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Article

Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.

Journal of lipid research - 1 Aug 2017

Alvarez Rafael, Casas Jesús, López David J, Ibarguren Maitane, Suari-Rivera Ariadna, Terés Silvia, Guardiola-Serrano Francisca, Lossos Alexander, Busquets Xavier, Kakhlon Or, Escribá Pablo V

Abstract excerpt

Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) (GBE1Y329S) yielding less branched, globular, and soluble glycogen, which tends to aggregate. We explore here whether, despite being a soluble enzyme, GBE1 activity is regulated by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28630259
DOI: 10.1194/jlr.M075531
PMCID: PMC5538282

Genes

GBE1
TGM5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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