Microglia in colony-stimulating factor 1-deficient op/op mice.

Abstract excerpt

Mice that are homozygous for the autosomal recessive mutation osteopetrosis (op) suffer from a general skeletal sclerosis, and the numbers of macrophages in various tissues are significantly decreased. We report that microglia in op/op mice are not affected by the mutation. They have normal morphology and are present in the CNS in normal frequency. In cultures, disaggregated cells of neopallia can form microglia,...

Topics

• Animals
• Astrocytes
• Cells, Cultured
• Colony-Stimulating Factors
• Female
• Immunohistochemistry
• Interleukin-3
• Male
• Mice
• Mice, Mutant Strains
• Microglia
• Mutation