Article
Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice.
Brain research - 31 Aug 1998
Wegiel J, Wiśniewski H M, Dziewiatkowski J, Tarnawski M, Kozielski R, Trenkner E, Wiktor-Jedrzejczak W
Abstract excerpt
The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, mic...
Topics
- Animals
- Brain
- Cell Count
- Corpus Callosum
- Frontal Lobe
- Immunohistochemistry
- Macrophage Colony-Stimulating Factor
- Male
- Mice
- Mice, Inbred Strains
- Microglia
- Mutation
- Osteopetrosis
- Parietal Lobe