Article
Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset.
Carcinogenesis - 1 Jul 1995
Chenevix-Trench G, Young J, Coggan M, Board P
Abstract excerpt
The M1 member of the Mu subclass of glutathione S-transferase (GSTM1) is only expressed in about 50% of individuals. In contrast, GSTT1, a member of the theta class which has been recently shown to be polymorphic, is expressed in 85% of Australian individuals. Previous studies have shown a signif...
Topics
- Adenocarcinoma
- Aged
- Aging
- Base Sequence
- Colonic Neoplasms
- Gene Deletion
- Genes, myc
- Genes, ras
- Genotype
- Glutathione Transferase
- Heterozygote
- Homozygote
- Humans
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic