Article
Possible influence of glutathione S-transferase GSTT1 null genotype on age of onset of sporadic colorectal adenocarcinoma.
Diseases of the colon and rectum - 1 Apr 2003
Nascimento Helvia, Coy Claudio S R, Teori Maria T, Boin Ilka F S F, Góes Juvenal R N, Costa Fernando F, Lima Carmen S P
Abstract excerpt
INTRODUCTION: Glutathione S-transferase enzymes mediate exposure to cytotoxic and genotoxic agents and may be involved in cancer susceptibility. Both glutathione S-transferase mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent. The association of glutathione S-transferase null genotype and risk of developing colorectal cancer is not yet fully clarified....
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