Article
Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt.
Cancer letters - 19 Jul 1999
Abdel-Rahman S Z, Soliman A S, Bondy M L, Wu X, El-Badawy S A, Mahgoub K G, Ismail S, Seifeldin I A, Levin B
Abstract excerpt
Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55...
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