Article
Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease: unnoticed congenital anomalies?
Congenital anomalies - 1 Dec 2010
Otani Hiroki, Udagawa Jun, Hatta Toshihisa, Kagohashi Yukiko, Hashimoto Ryuju, Matsumoto Akihiro, Satow Fumio, Nimura Masayuki
Abstract excerpt
Morphological studies of congenital anomalies have mainly focused on abnormal shape (i.e. malformation) and thus on disturbed organogenesis. However, in regard to postnatal functions of organs that develop through branching mechanisms, organ size is another important morphological feature. These organs consist of a large number of structural and functional units, such as nephrons in the kidney, and the total...
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