Polymorphism of immunoglobulin heavy chain switch region gene in children with severe IgA nephropathy.

Article

Polymorphism of immunoglobulin heavy chain switch region gene in children with severe IgA nephropathy.

Clinical nephrology - 1 Apr 1995

Shimomura M, Yoshikawa N, Iijima K, Nakamura H, Miyazaki M, Sakai H

Abstract excerpt

We examined restriction fragment length polymorphisms (RFLPs) of the switch region genes of the IgM (S mu) and IgA1 (S alpha 1) heavy chain in 78 Japanese children with IgA nephropathy and 88 normal Japanese controls. Genomic DNA obtained from patients and controls was digested with the restricti...

Topics

Alleles
Child
Female
Genes, Immunoglobulin
Glomerulonephritis, IGA
Humans
Immunoglobulin Switch Region
Male
Polymorphism, Genetic

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