Article
Polymorphism of immunoglobulin heavy chain switch region gene in children with severe IgA nephropathy.
Clinical nephrology - 1 Apr 1995
Shimomura M, Yoshikawa N, Iijima K, Nakamura H, Miyazaki M, Sakai H
Abstract excerpt
We examined restriction fragment length polymorphisms (RFLPs) of the switch region genes of the IgM (S mu) and IgA1 (S alpha 1) heavy chain in 78 Japanese children with IgA nephropathy and 88 normal Japanese controls. Genomic DNA obtained from patients and controls was digested with the restriction endonuclease SacI, transferred to nylon membrane using Southern blot procedure, and hybridized with a DNA probe...
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