Article
[Polymorphism of immunoglobulin heavy chain switch region in IgA nephropathy].
Nihon rinsho. Japanese journal of clinical medicine - 1 Dec 1992
Miyazaki M, Sakai H
Abstract excerpt
We examined the relation between IgA hyperproduction and polymorphism of the immunoglobulin heavy chain switch (S) region in patients with IgA nephropathy. The frequency of the heterozygous phenotype of IgA2 switch region was significantly increased in these patients. The patients showed a significant increase in the amount of serum IgA, IgA bearing cells and levels of proteinuria. We also compared two reports on...
Topics
- Glomerulonephritis, IGA
- Humans
- Immunoglobulin A
- Immunoglobulin Heavy Chains
- Immunoglobulin Switch Region
- Phenotype
- Polymorphism, Genetic
- Proteinuria