Article
Increased frequency of the heterozygous switch region of IgA2 in Japanese patients with IgA nephropathy.
Internal medicine (Tokyo, Japan) - 1 Aug 1992
Miyazaki M, Kashem A, Ihara S, Yano N, Endoh M, Nomoto Y, Sakai H
Abstract excerpt
The relation between IgA hyperproduction and restriction fragment length polymorphism (RFLP) of the immunoglobulin heavy chain switch (S) region was examined in Japanese patients with IgA nephropathy (IgAN) using Southern blot hybridization. Polymorphism in the S regions of IgM, IgA1 and IgA2 (SA2) was detected. A significant increase in the frequency of heterozygous phenotype of SA2 was shown in the patients....
Topics
- Adult
- Alleles
- Blotting, Southern
- Gene Frequency
- Glomerulonephritis, IGA
- Glomerulonephritis, Membranoproliferative
- Humans
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulin Switch Region